In 1986, at the age of twenty-two, Alfonso Artiaco launched his gallery in Pozzuoli, on Corso Nicola Terracciano, with the group exhibition Possibilità di collezione. The works on exhibit, collected over time, were by such artists as Carlo Alfano, Alighiero Boetti, Joseph Beuys, Enzo Cucchi, Luciano Fabro, Nino Longobardi, Luigi Ontani, Giulio Paolini, Mario Schifano, and Andy Warhol.
After this first exhibition, the gallery narrowed its field of action, focusing heavily on Arte Povera, conceptual and minimal art, confirmed with exhibitions by Richard Artschwager, Giuseppe Penone, Niele Toroni, Giovanni Anselmo, Wolfgang Laib and Lawrence Weiner. In 1995, the gallery was temporarily moved to Via Mameli in Pozzuoli, with an inaugural exhibition by Carl Andre and Sol LeWitt. In 1997, the gallery returned to its first location, with a solo exhibition by Jannis Kounellis. In 2003, the gallery moved to Naples, in Piazza dei Martiri. There, in 2010, it opened another space with an exhibition by Magnus Plessen. In November 2012, the gallery opened its present location in Piazzetta Nilo with an exhibition by Liam Gillick and a tribute to Sol LeWitt.